Epalrestat, Ono-2235, Kinedak-药物合成数据库

【药物名称】Epalrestat, Ono-2235, Kinedak

化学结构式(Chemical Structure):

参考文献No.	39863
标题:	Rhodanine derivs., process for their preparation,
作者:	Hiroshi, T.; Tetsuya, M.; Takeshi, M.; Akio, A.; Masanori, K.; Fumio, H.; Tadao, T.; Masaki, H. (Ono Pharmaceutical Co., Ltd.)
来源:	EP 0047109; US 4464382

合成路线图解说明: By condensation of beta-methylcinnamylaldehyde (I) with 3-(carboxymethyl)rhodanine (II) by means of sodium acetate in refluxing acetic acid.

参考文献No.	64813
标题:	Epalrestat
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1987,12(4),336

合成路线图解说明: By condensation of beta-methylcinnamylaldehyde (I) with 3-(carboxymethyl)rhodanine (II) by means of sodium acetate in refluxing acetic acid.