【药物名称】Rilmenidine dihydrogen phosphate, S-3341, Hyperium
化学结构式(Chemical Structure):
参考文献No.46545
标题:Cyclopropylamines as pharmaceuticals
作者:Malen, C.; Desnos, M.; Laubie, M.; Poignant, J.C. (Servier Laboratoires)
来源:DE 2362754; ES 421879; FR 2212143; GB 1453703; JP 50004084; JP 53056664; JP 53056665
合成路线图解说明:

The addition of dicyclopropylmethylamine (II) to B-chloroethyl isocyanate (I) in THF gives N-(dicyclopropylmethyl)-N'-(Beta-chloroethyl)urea (III), which is then cyclized in refluxing water.

参考文献No.62308
标题:S-3341
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1986,11(6),470
合成路线图解说明:

The addition of dicyclopropylmethylamine (II) to B-chloroethyl isocyanate (I) in THF gives N-(dicyclopropylmethyl)-N'-(Beta-chloroethyl)urea (III), which is then cyclized in refluxing water.

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