【药物名称】Premazepam, MDL-181, DL-181
化学结构式(Chemical Structure):
参考文献No.66415
标题:Premazepam
作者:Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1984,9(7),520
合成路线图解说明:

The reaction of 1,2-dimethyl-3-benzoyl-4-aminopyrrole (I) with phthalimidoacetyl chloride (II) by means of NaOH gives 1,2-dimethyl-3-benzoyl-4-(phthalimidoacetamido)pyrrole (III), which is cyclized by reaction with hydrazine in refluxing methanol.

参考文献No.701194
标题:Pharmacologically active pyrrolodiazepines
作者:Fontanella, L.; Mariani, L.; Tarzia, G.
来源:DE 2511599; FR 2264546; GB 1433103; JP 50135094; US 4022766; US 4022766
合成路线图解说明:

The reaction of 1,2-dimethyl-3-benzoyl-4-aminopyrrole (I) with phthalimidoacetyl chloride (II) by means of NaOH gives 1,2-dimethyl-3-benzoyl-4-(phthalimidoacetamido)pyrrole (III), which is cyclized by reaction with hydrazine in refluxing methanol.

参考文献No.800314
标题:3,7-Dihydro-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-ones. Synthesis and pharmaclogical properties
作者:Corsico, N.; Tarzia, G.; Fontanella, L.; Mariani, L.
来源:Eur J Med Chem - Chim Ther 1976,11(3),217-220
合成路线图解说明:

The reaction of 1,2-dimethyl-3-benzoyl-4-aminopyrrole (I) with phthalimidoacetyl chloride (II) by means of NaOH gives 1,2-dimethyl-3-benzoyl-4-(phthalimidoacetamido)pyrrole (III), which is cyclized by reaction with hydrazine in refluxing methanol.

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