The cyclization of N1-(2-fluorobenzoyl)-N2-methyl-N2-phenyl-2-hydroxy-1,3-diaminopropane (I) with refluxing POCl3 gives 1-methyl-2-chloromethyl-5-(2-fluorophenyl)-1H-2,3-dihydro-1,4-benzodiazepine (II), which by condensation with potassium phthalimide (III) in refluxing methanol yields the corresponding phthalimido derivative (IV). The cleavage of (IV) with hydrazine in refluxing ethanol affords 1-methyl-2-aminomethyl-5-(2-fluorophenyl)-1H-2,3-dihydro-1,4-benzodiazepine (V), which is finally condensed with thiophene-3-carbonyl chloride (VI) by means of triethylamine in methylene chloride.

The cyclization of N1-(2-fluorobenzoyl)-N2-methyl-N2-phenyl-2-hydroxy-1,3-diaminopropane (I) with refluxing POCl3 gives 1-methyl-2-chloromethyl-5-(2-fluorophenyl)-1H-2,3-dihydro-1,4-benzodiazepine (II), which by condensation with potassium phthalimide (III) in refluxing methanol yields the corresponding phthalimido derivative (IV). The cleavage of (IV) with hydrazine in refluxing ethanol affords 1-methyl-2-aminomethyl-5-(2-fluorophenyl)-1H-2,3-dihydro-1,4-benzodiazepine (V), which is finally condensed with thiophene-3-carbonyl chloride (VI) by means of triethylamine in methylene chloride.