【药物名称】Cefminox sodium, MT-141, Alteporina, Tencef, Meicelin
化学结构式(Chemical Structure):
参考文献No.46762
标题:7alpha-Methoxycephalosporin derivatives
作者:Iwamatsu, K.; Inoue, S.; Miyauchi, K.; Kondo, S.; Seki, S.; Yamada, Y. (Meiji Seika Kaisha, Ltd.)
来源:JP 55083791
合成路线图解说明:

The reaction of 7-beta-bromoacetamido-7-alphamethoxycephalosporanic acid (I) with D-cysteine (II) in water at pH 7 gives 7-(2-aminocarboxyethylthio)acetamido-7-alpha-methoxycephalosporanic acid (III), which is then condensed with 5-mercapto-1-methyl-1H-tetrazole (IV) in water at pH 6.5-7 and at 60 C.

参考文献No.49372
标题:MT-141
作者:Blancafort, P.; Casta馿r, J.; Loren, J.G.; Serradell, M.N.
来源:Drugs Fut 1982,7(6),395
合成路线图解说明:

The reaction of 7-beta-bromoacetamido-7-alphamethoxycephalosporanic acid (I) with D-cysteine (II) in water at pH 7 gives 7-(2-aminocarboxyethylthio)acetamido-7-alpha-methoxycephalosporanic acid (III), which is then condensed with 5-mercapto-1-methyl-1H-tetrazole (IV) in water at pH 6.5-7 and at 60 C.

参考文献No.605737
标题:Synthesis and biological activity of 7beta-(2-amino-2-carboxy)-ethylthioacetamido-7alpha-methoxycephalosporin derivatives
作者:Iwamatsu, K.; Inouye, S.; Tsuruoka, T.; Mizutani, K.; Omoto, S.; Ogino, H.; Miyauchi, K.; Watanabe, T.; Niida, T.
来源:J Antibiot 1983,36(3),229-241
合成路线图解说明:

A new method for the synthesis of MT-141 has been reported: By condensation of 7-bromoacetamido-7alpha-methoxy-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (I) with D-cysteine (II) in aqueous NaHCO3.

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