【药物名称】Cadralazine, CGP-18684/E, ISF-2469, Cadrilan, Cadraten
化学结构式(Chemical Structure):
参考文献No.46761
标题:6-Substituted 3-carbethoxyhydrazinopyridazines
作者:Carpi, C.; Dorigotti, L.; Pifferi, G. (ISF SpA)
来源:US 4002753
合成路线图解说明:

This compound can be prepared by two related ways: 1) The reaction of ethyl (2-hydroxypropyl)amine (A) with 3,6-dichloropyridazine (I) in refluxing toluene gives 3-chloro-6-[ethyl(2-hydroxypropyl)amino]pyridazine (II). This intermediate is then reacted with ethyl hydrazinecarboxylate (B) to afford (III). 2) Alternatively, compound (II) may be treated with hydrazine hydrate to afford the hydrazinopyridazine (IV); acylation of (IV) with ethoxycarbonyl chloride provides the final compound (III).

参考文献No.49371
标题:Cadralazine
作者:Meran, C.
来源:Drugs Fut 1982,7(6),382
合成路线图解说明:

This compound can be prepared by two related ways: 1) The reaction of ethyl (2-hydroxypropyl)amine (A) with 3,6-dichloropyridazine (I) in refluxing toluene gives 3-chloro-6-[ethyl(2-hydroxypropyl)amino]pyridazine (II). This intermediate is then reacted with ethyl hydrazinecarboxylate (B) to afford (III). 2) Alternatively, compound (II) may be treated with hydrazine hydrate to afford the hydrazinopyridazine (IV); acylation of (IV) with ethoxycarbonyl chloride provides the final compound (III).

参考文献No.800189
标题:Derivati della 3-idrazinopiridazina. Nota III. Sintesi ed attivit?antiipertensiva di nuove 3-(2-acilidrazino)piridazine-6-alchilamino sostituite
作者:Pifferi, G.; Parravicini, F.; Scarpitta, G.; Dorigotti, L.
来源:Farm Sci Ed 1979,34299-310
合成路线图解说明:

This compound can be prepared by two related ways: 1) The reaction of ethyl (2-hydroxypropyl)amine (A) with 3,6-dichloropyridazine (I) in refluxing toluene gives 3-chloro-6-[ethyl(2-hydroxypropyl)amino]pyridazine (II). This intermediate is then reacted with ethyl hydrazinecarboxylate (B) to afford (III). 2) Alternatively, compound (II) may be treated with hydrazine hydrate to afford the hydrazinopyridazine (IV); acylation of (IV) with ethoxycarbonyl chloride provides the final compound (III).

参考文献No.800190
标题:Analytical profile of cadralazine, a new antihypttensive agent
作者:Citero, L.; Visconti, M.; Borsa, M.; Pifferi, G.
来源:Boll Chim Farm 1981,120222-233
合成路线图解说明:

This compound can be prepared by two related ways: 1) The reaction of ethyl (2-hydroxypropyl)amine (A) with 3,6-dichloropyridazine (I) in refluxing toluene gives 3-chloro-6-[ethyl(2-hydroxypropyl)amino]pyridazine (II). This intermediate is then reacted with ethyl hydrazinecarboxylate (B) to afford (III). 2) Alternatively, compound (II) may be treated with hydrazine hydrate to afford the hydrazinopyridazine (IV); acylation of (IV) with ethoxycarbonyl chloride provides the final compound (III).

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