B-77781-药物合成数据库

【药物名称】B-77781

化学结构式(Chemical Structure):

参考文献No.	47217
标题:	Anti-depressant and analgesic 4-phenoxypiperidines
作者:	Eistetter, K.; Kley, H.-P.; Menge, H.G.; Schaefer, H. (Byk Gulden Lomberg Chemische Fabrik GmbH)
来源:	US 4333942

合成路线图解说明: Reaction of 1-methyl-4-piperidone (I) with phenyllithium (II) gives 1-methyl-4-phenyl-4-piperidinol (III), which is alkylated with (IV) in NaH/DMF to yield (V), followed by reduction with hydrazine/Raney-Ni.

参考文献No.	65796
标题:	B-777-81
作者:	Menge, H.G.; Eistetter, K.; Schaefer, H.; Kley, H.-P.
来源:	Drugs Fut 1983,8(5),387

合成路线图解说明: Reaction of 1-methyl-4-piperidone (I) with phenyllithium (II) gives 1-methyl-4-phenyl-4-piperidinol (III), which is alkylated with (IV) in NaH/DMF to yield (V), followed by reduction with hydrazine/Raney-Ni.