Nevadensin can be synthesized starting from methyl 2,6-dimethoxyphenyl acetate (I). This compound is nitrated and then hydrogenated, giving methyl 3,5-diamino-2,6-dimethoxyphenyl acetate (III). Treatment of the latter compound with stannous chloride-hydrochloric acid gives dimethoxyphloroglucinol (IV). Introduction of an acetyl group followed by interaction with p-methoxybenzoyl chloride (A) gives 4-acetyl-2,6-dimethoxyphloroglucinyl tri(p-methoxy) benzoate (VI). The latter compound, after being rearranged, is cyclized into 5,7-di(p-methoxy)benzoylnevadensin (VIII). Nevadensin can readily be obtained by the hydrolysis of the compound (VIII).

Nevadensin can be synthesized starting from methyl 2,6-dimethoxyphenyl acetate (I). This compound is nitrated and then hydrogenated, giving methyl 3,5-diamino-2,6-dimethoxyphenyl acetate (III). Treatment of the latter compound with stannous chloride-hydrochloric acid gives dimethoxyphloroglucinol (IV). Introduction of an acetyl group followed by interaction with p-methoxybenzoyl chloride (A) gives 4-acetyl-2,6-dimethoxyphloroglucinyl tri(p-methoxy) benzoate (VI). The latter compound, after being rearranged, is cyclized into 5,7-di(p-methoxy)benzoylnevadensin (VIII). Nevadensin can readily be obtained by the hydrolysis of the compound (VIII).

Nevadensin can be synthesized starting from methyl 2,6-dimethoxyphenyl acetate (I). This compound is nitrated and then hydrogenated, giving methyl 3,5-diamino-2,6-dimethoxyphenyl acetate (III). Treatment of the latter compound with stannous chloride-hydrochloric acid gives dimethoxyphloroglucinol (IV). Introduction of an acetyl group followed by interaction with p-methoxybenzoyl chloride (A) gives 4-acetyl-2,6-dimethoxyphloroglucinyl tri(p-methoxy) benzoate (VI). The latter compound, after being rearranged, is cyclized into 5,7-di(p-methoxy)benzoylnevadensin (VIII). Nevadensin can readily be obtained by the hydrolysis of the compound (VIII).