Pirlimycin hydrochloride, U-57930E-药物合成数据库

【药物名称】Pirlimycin hydrochloride, U-57930E

化学结构式(Chemical Structure):

参考文献No.	47445
标题:	Novel antibiotics, their preparation and their use
作者:	Birkenmeyer, R.D. (Pharmacia Corp.)
来源:	BE 0886301

合成路线图解说明: The condensation of 4-ethylpyridine-2-carboxylic acid (I) with methyl-6-amino-7-chloro-6,7,8-trideoxy-1-thio-L-threo-alpha-D-galacto-octopyranoside (II) by means of isobutyl chloroformate (A) and triethylamine in acetonitrile gives the corresponding amide (III), which is then hydrogenated with H2 over PtO2 in methanol - water - HCl.

参考文献No.	800352
标题:	Pirlimycin hydrochloride
作者:	Hillier, K.; Serradell, M.N.; Blancafort, P.; Casta馿r, J.
来源:	Drugs Fut 1983,8(4),338

合成路线图解说明: The condensation of 4-ethylpyridine-2-carboxylic acid (I) with methyl-6-amino-7-chloro-6,7,8-trideoxy-1-thio-L-threo-alpha-D-galacto-octopyranoside (II) by means of isobutyl chloroformate (A) and triethylamine in acetonitrile gives the corresponding amide (III), which is then hydrogenated with H2 over PtO2 in methanol - water - HCl.