Mefenidil, McN-2378-46(fumarate), McN-2378-药物合成数据库

【药物名称】Mefenidil, McN-2378-46(fumarate), McN-2378

化学结构式(Chemical Structure):

参考文献No.	64773
标题:	McN-2378
作者:	Blancafort, P.; Hillier, K.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1982,7(4),262

合成路线图解说明: The cyclization of benzamidine (I) with biacetyl (II) in water - isopropanol gives 4,5-dimethyl-2-phenylimidazoline-4,5-diol (III), which by treatment with refluxing aqueous 10% HCl is converted into 4-hydroxymethyl-2-phenyl-5-methylimidazole (IV). The reaction of (IV) with SOCl2 in refluxing benzene yields 4-chloromethyl-2-phenyl-5-methylimidazole (V), which is finally treated with NaCN in DMSO - water.

参考文献No.	701310
标题:	2-Aryl-4-cyanomethyl-5-methylimidazoles
作者:	Rasmussen, C.R.
来源:	DE 2528640; FR 2296627; FR 2309540; FR 2309541; GB 1502142; JP 51034159; US 4093811

合成路线图解说明: The cyclization of benzamidine (I) with biacetyl (II) in water - isopropanol gives 4,5-dimethyl-2-phenylimidazoline-4,5-diol (III), which by treatment with refluxing aqueous 10% HCl is converted into 4-hydroxymethyl-2-phenyl-5-methylimidazole (IV). The reaction of (IV) with SOCl2 in refluxing benzene yields 4-chloromethyl-2-phenyl-5-methylimidazole (V), which is finally treated with NaCN in DMSO - water.