Fenoximone, Enoximone, MDL-17043, RMI-17043, Perfan, Perfane-药物合成数据库

【药物名称】Fenoximone, Enoximone, MDL-17043, RMI-17043, Perfan, Perfane

化学结构式(Chemical Structure):

参考文献No.	46457
标题:	4-Aroylimidazol-2-ones
作者:	Dage, R.C.; Schnettler, R.A.; Grisar, J.M. (Aventis Pharmaceuticals, Inc.)
来源:	BE 0883856; DE 3021792; FR 2459233; GB 2055364; JP 56005463

合成路线图解说明: The reaction of 4-(methylthio)benzoic acid (I) with SOCl2 in refluxing benzene gives 4-(methylthio)benzoyl chloride (II), which is then condensed with 1,3-dihydro-4-methyl-2H-imidazol-2-one (III) by means of AlCl3 in hot nitrobenzene.

参考文献No.	65176
标题:	RMI-17,043
作者:	Pento, J.T.; Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1983,8(4),343

合成路线图解说明: The reaction of 4-(methylthio)benzoic acid (I) with SOCl2 in refluxing benzene gives 4-(methylthio)benzoyl chloride (II), which is then condensed with 1,3-dihydro-4-methyl-2H-imidazol-2-one (III) by means of AlCl3 in hot nitrobenzene.