Rimcazole hydrochloride, SH 1/76(monohydrochloride), BW-234U(free base)-药物合成数据库

【药物名称】Rimcazole hydrochloride, SH 1/76(monohydrochloride), BW-234U(free base)

化学结构式(Chemical Structure):

参考文献No.	47215
标题:	Carbazole compounds and medicinal use thereof
作者:	Harfenist, M.; Jogner, C.T. (Glaxo Wellcome Inc.)
来源:	DD 147110; EP 0012208; EP 0051321; US 4379160

合成路线图解说明: The reaction of 3-chloropropanol (I) with 2,6-dimethylpiperazine (II) by means of Na2CO3 in refluxing glycol monomethyl ether gives 3-(3,5-dimethyl-1-piperazinyl)propanol (III), which by reaction with refluxing SOCl2 is converted into 3-(3,5-dimethylpiperazinyl)propyl chloride (IV). Finally, this compound is condensed with carbazole (V) by means of NaH in hot DMF; a final treatment with aqueous HCl yields the dihydrochloride.

参考文献No.	64777
标题:	BW-234U
作者:	Blancafort, P.; Hilier, K.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1983,8(4),303

合成路线图解说明: The reaction of 3-chloropropanol (I) with 2,6-dimethylpiperazine (II) by means of Na2CO3 in refluxing glycol monomethyl ether gives 3-(3,5-dimethyl-1-piperazinyl)propanol (III), which by reaction with refluxing SOCl2 is converted into 3-(3,5-dimethylpiperazinyl)propyl chloride (IV). Finally, this compound is condensed with carbazole (V) by means of NaH in hot DMF; a final treatment with aqueous HCl yields the dihydrochloride.