【药物名称】DuP-923(diHCl), ACC-9358
化学结构式(Chemical Structure):
参考文献No.63564
标题:ACC-9358
作者:Serradell, M.N.; Casta馿r, J.
来源:Drugs Fut 1986,11(3),169
合成路线图解说明:

The reaction of aniline (I) with 4-hydroxybenzoic acid (II) by means of P2O5 in refluxing toluene gives N-(4-hydroxybenzoyl)aniline (III), which is then condensed with pyrrolidine (IV) and formaldehyde (V) in refluxing ethanol.

参考文献No.607711
标题:Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 3. Modifications to the linkage region (Region 3(
作者:Stout, D.M.; Matier, W.L.; Barcelon-Yang, C.; Reynolds, R.D.; Brown, B.S.
来源:J Med Chem 1985,28(3),295-298
合成路线图解说明:

The reaction of aniline (I) with 4-hydroxybenzoic acid (II) by means of P2O5 in refluxing toluene gives N-(4-hydroxybenzoyl)aniline (III), which is then condensed with pyrrolidine (IV) and formaldehyde (V) in refluxing ethanol.

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