Carboxyimamidate, Carbetimer, NSC-329514D, NED-137, N-137, Plimar, Polima-药物合成数据库

【药物名称】Carboxyimamidate, Carbetimer, NSC-329514D, NED-137, N-137, Plimar, Polima

化学结构式(Chemical Structure):

参考文献No.	63611
标题:	N-137
作者:	Hopkins, S.J.; Casta馿r, J.; Serradell, M.N.; Blancafort, P.
来源:	Drugs Fut 1983,8(3),210

合成路线图解说明: The copolymerization of ethylene (III) and maleic anhydride (II) in ethylbenzene (I) by means of benzoyl peroxide (IV) at 70 C gives an ethylene/maleic anhydride copolymer (V), which is ammoniated by treating with liquid ammonia in acetone yielding the ammoniated ethylene/maleic acid copolymer (VI). Finally, this product is imidated partially by heating in refluxing xylene.

参考文献No.	607574
标题:	Carboxyimidate, a low-molecular-weight polyelectrolyte with antitumor properties and low toxixity
作者:	Fields, J.E.; Asculai, S.S.; Johnson, J.H.; Johnson, R.K.
来源:	J Med Chem 1982,25(9),1060-64

合成路线图解说明: The copolymerization of ethylene (III) and maleic anhydride (II) in ethylbenzene (I) by means of benzoyl peroxide (IV) at 70 C gives an ethylene/maleic anhydride copolymer (V), which is ammoniated by treating with liquid ammonia in acetone yielding the ammoniated ethylene/maleic acid copolymer (VI). Finally, this product is imidated partially by heating in refluxing xylene.