Impromidine hydrochloride, SK&F-92676-A3-药物合成数据库

【药物名称】Impromidine hydrochloride, SK&F-92676-A3

化学结构式(Chemical Structure):

参考文献No.	701477
标题:
作者:	Durant, G.J.; et al.
来源:	US 4013659

合成路线图解说明: The reaction of N-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]thiourea (I) with methyl iodide in methanol gives the corresponding thiouronium iodide (II), which is converted into the sulfate by treatment with IRA 401 ion-exchange resin. Finally, this sulfate is condensed with 4-(3-aminopropyl)imizadole (III) in refluxing water.

参考文献No.	800531
标题:	Impromidine
作者:	Serradell, M.N.; Hopkins, S.J.; Blancafort, P.; Casta馿r, J.
来源:	Drugs Fut 1979,4(9),647

合成路线图解说明: The reaction of N-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]thiourea (I) with methyl iodide in methanol gives the corresponding thiouronium iodide (II), which is converted into the sulfate by treatment with IRA 401 ion-exchange resin. Finally, this sulfate is condensed with 4-(3-aminopropyl)imizadole (III) in refluxing water.