Arachidonic acid (I) is reduced with LiAlH4 to the primary alcohol (II), which is subsequently brominated to (III) upon treatment with CBr4 and PPh3. After conversion of bromide (III) into the corresponding Grignard reagent, reaction with sulfuryl chloride furnishes the sulfononic acid chloride (IV). Finally, chloride (IV) is converted into the title sulfonyl fluoride by displacement with tetrabutylammonium fluoride in THF.