【药物名称】
化学结构式(Chemical Structure):
参考文献No.743108
标题:4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
作者:Manetti, D.; Martini, E.; Ghelardini, C.; Dei, S.; Galeotti, N.; Guandalini, L.; Romanelli, M.N.; Scapecchi, S.; Teodori, E.; Bartolini, A.; Gualtieri, F.
来源:Bioorg Med Chem Lett 2003,13(14),2303
合成路线图解说明:

Acylation of 4-amino-1-benzylpiperidine (I) with acetyl chloride provides the amide (II). Subsequent debenzylation of (II) by transfer hydrogenation with ammonium formate in the presence of Pd/C yields the piperidine (III), which is finally acylated with 4-fluorobenzenesulfonyl chloride (IV) to give the corresponding sulfonamide.

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