SIM-01-药物合成数据库

【药物名称】SIM-01

化学结构式(Chemical Structure):

参考文献No.	61471
标题:	Dihydroporphyrin derivs. and their uses
作者:	Bourre, L.; Patrice, T.
来源:	EP 1305317; FR 2812637; US 2004022734; WO 0210173

合成路线图解说明: Acid-catalyzed condensation of dipyrrolylmethane (I) with 3,5-dimethoxybenzaldehyde (II) gives rise to the porphyrin derivative (III). Subsequent demethylation of the methoxy groups of (III) employing BBr3 affords the tetraphenol compound (IV). Finally, partial reduction of (IV) by means of p-toluenesulfonyl hydrazide in hot pyridine furnishes the title compound (1,2).

参考文献No.	725616
标题:	Synthesis, and in vitro and in vivo evaluation of a diphenylchlorin sensitizer for photodynamic therapy
作者:	Bourr? L.; Simmoneaux, G.; Ferrand, Y.; Thibaut, S.; Lajat, Y.; Patrice, T.
来源:	J Photochem Photobiol B Biol 2003,69(3),179

合成路线图解说明: Acid-catalyzed condensation of dipyrrolylmethane (I) with 3,5-dimethoxybenzaldehyde (II) gives rise to the porphyrin derivative (III). Subsequent demethylation of the methoxy groups of (III) employing BBr3 affords the tetraphenol compound (IV). Finally, partial reduction of (IV) by means of p-toluenesulfonyl hydrazide in hot pyridine furnishes the title compound (1,2).