【药物名称】
化学结构式(Chemical Structure):
参考文献No.723669
标题:Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction
作者:Isobe, Y.; Tobe, M.; Inoue, Y.; Goto, Y.; Obara, F.; Isobe, M.; Hayashi, H.
来源:Chem Pharm Bull 2003,51(3),309
合成路线图解说明:

Nitrosation of pyrimidinedione (I) with NaNO2/HCl affords (II), which is further reduced to the diaminopyrimidine (III) by catalytic hydrogenation over Pd/C. Subsequent coupling of (III) with 2,6-di-tert-butyl-4-hydroxycinnamic acid (IV) employing DPP-Cl furnishes the title amide

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