【药物名称】BMS-345541
化学结构式(Chemical Structure):
参考文献No.56855
标题:Methods of treating inflammatory and immune diseases using inhibitors of IkappaB kinase (IKK)
作者:Zusi, F.C.; Burke, J.R.; Townsend, R.M.; Qiu, Y.; Nadler, S. (Bristol-Myers Squibb Co.)
来源:EP 1363993; US 2002072523; WO 0260386
合成路线图解说明:

Decarboxylation of the tricyclic carboxylic acid (I) in boiling diphenyl ether leads to (II). This is further chlorinated to (III) employing POCl3 in the presence of N,N-diethylaniline. Then, displacement of chloride (III) with ethylenediamine at 60癈 gives rise to the title compound, which is finally isolated as the corresponding hydrochloride salt.

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