【药物名称】
化学结构式(Chemical Structure):
参考文献No.59229
标题:Cpds. and methods for the treatment or prevention of flavivirus infections
作者:Pereira, O.Z.; Wang, W.; Siddiqui, M.A.; B閐ard, J.; Nguyen Ba, N.; Chan, C.K.L.; Das, S.K.; Shuttleworth, S. (Shire BioChem Inc.)
来源:US 2003229053; WO 02100846
合成路线图解说明:

Acylation of L-phenylalanine tert-butyl ester (I) with 2,4-dichlorobenzoyl chloride (II) provides the corresponding amide (III). This is then N-alkylated with 3-nitrobenzyl bromide (IV) in the presence of NaH to yield (V). The tert-butyl ester group of (V) is finally cleaved with trifluoroacetic acid to furnish the target carboxylic acid. (1-3)

参考文献No.721723
标题:Identification of a novel class of inhibitors of hepatitis C NS5B polymerase
作者:Proulx, M.; Chan, L.; Reddy, T.J.; Das, S.K.; Pereira, O.Z.
来源:225th ACS Natl Meet (March 23 2003, New Orleans) 2003,Abst MEDI 40
合成路线图解说明:

Acylation of L-phenylalanine tert-butyl ester (I) with 2,4-dichlorobenzoyl chloride (II) provides the corresponding amide (III). This is then N-alkylated with 3-nitrobenzyl bromide (IV) in the presence of NaH to yield (V). The tert-butyl ester group of (V) is finally cleaved with trifluoroacetic acid to furnish the target carboxylic acid. (1-3)

参考文献No.722888
标题:Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase
作者:Chan, L.; Reddy, J.; Proulx, M.; Das, S.K.; Pereira, O.; Wang, W.; Siddiqui, A.; Yannopoulos, C.G.; Poisson, C.; Turcotte, N.; Drouin, A.; Alaoui-Ismaili, M.H.; Bethell, R.; Hamel, M.; L'Heureux, L.; Bilimoria, D.; Nguyen-Ba, N.
来源:J Med Chem 2003,46(8),1283
合成路线图解说明:

Acylation of L-phenylalanine tert-butyl ester (I) with 2,4-dichlorobenzoyl chloride (II) provides the corresponding amide (III). This is then N-alkylated with 3-nitrobenzyl bromide (IV) in the presence of NaH to yield (V). The tert-butyl ester group of (V) is finally cleaved with trifluoroacetic acid to furnish the target carboxylic acid. (1-3)

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