Acylation of cis-2,6-dimethylpiperazine (I) with dimethylcarbamoyl chloride affords urea (II) (1,2). (R)-2-Methoxypropionamidine (III) is reacted with cyanogen bromide to produce the N-cyano amidine (IV) (1). Treatment of the carbamoyl piperazine (II) with POCl3, followed by condensation with cyanoamidine (IV) in refluxing acetonitrile gives rise to the piperazinyl triazine (V), which is condensed with 2,4-dichloro-6-methyltriazine (VI) yielding the bis-triazinyl piperazine (VII). Dehalogenation of (VII) by transfer hydrogenation with Pd/C and ammonium formate produces (VIII), which is finally subjected to methyl ether cleavage with BBr3 to furnish the title compound (1,2).

Acylation of cis-2,6-dimethylpiperazine (I) with dimethylcarbamoyl chloride affords urea (II) (1,2). (R)-2-Methoxypropionamidine (III) is reacted with cyanogen bromide to produce the N-cyano amidine (IV) (1). Treatment of the carbamoyl piperazine (II) with POCl3, followed by condensation with cyanoamidine (IV) in refluxing acetonitrile gives rise to the piperazinyl triazine (V), which is condensed with 2,4-dichloro-6-methyltriazine (VI) yielding the bis-triazinyl piperazine (VII). Dehalogenation of (VII) by transfer hydrogenation with Pd/C and ammonium formate produces (VIII), which is finally subjected to methyl ether cleavage with BBr3 to furnish the title compound (1,2).