【药物名称】UCM-597, URB-597
化学结构式(Chemical Structure):
参考文献No.711523
标题:Modulation of anxiety through blockade of anandamide hydrolysis
作者:Kathuria, S.; Gaetani, S.; Fegley, D.; Vali駉, M.; Duranti, A.; Tontini, A.; Mor, M.; Tarzia, G.; La Rana, G.; Calignano, A.; Giustino, A.; Tattoli, M.; Palmery, M.; Cuomo, V.; Piomelli, D.
来源:Nat Med 2003,9(1),76
合成路线图解说明:

Hydrolysis of 3-bromobenzonitrile (I) by means of sodium perborate leads to amide (II). Subsequent Suzuki coupling of 3-bromobenzamide (II) with 3-methoxyphenylboronic acid (III) furnishes the biphenyl compound (IV). The methyl ether group of (IV) is then cleaved employing BBr3 to yield phenol (V). This is finally coupled with cyclohexyl isocyanate (VI) to produce the title carbamate.

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