Prolonged exposure of sordaricin (I) to Nocardia species SC11274 affords 7 hydroxysordaricin (II). Acid-promoted dehydration of the tertiary alcohol (II) using 6 N HCl in acetone generates 7,8-deshydrosordaricin (III), which is further protected as the benzyl ester (IV) upon treatment with O-benzyl diisopropyl isourea. Then, alkylation of the primary hydroxyl group of (IV) with 1 iodohexane (V) gives rise to the corresponding hexyl ether (VI). Finally, the benzyl ester group in (VI) is cleaved by hydrogenolysis to furnish the title compound.