【药物名称】
化学结构式(Chemical Structure):
参考文献No.711814
标题:In vitro inhibition of the measles virus by novel ring-expanded ('fat') nucleoside analogues containing the imidazo[4,5-e]diazepine ring system
作者:Zhang, N.; Chen, H.-M.; Sood, R.; Kalicharran, K.; Fattom, A.I.; Naso, R.B.; Barnard, D.L.; Sidwell, R.W.; Hosmane, R.S.
来源:Bioorg Med Chem Lett 2002,12(23),3391
合成路线图解说明:

Glycosylation of dimethyl 2-phenylimidazole-4,5-dicarboxylate (I) with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (II) in the presence of hexamethyldisilazane, chlorotrimethylsilane and trifluoromethanesulfonic acid leads to the imidazole ribofuranoside (III). Then, cyclization of the imidazoledicarboxylate (III) with guanidine (IV), and simultaneous alcoholysis of the ribose ester groups in the presence of methanolic NaOMe gives rise to the target imidazodiazepine ribofuranoside

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