【药物名称】Propofol phosphate
化学结构式(Chemical Structure):
参考文献No.41153
标题:Water-soluble pro-drugs of propofol
作者:Sanchez, R.A.; Hendler, S.S.; Zielinski, J. (Vyrex Corp.)
来源:JP 2002514656; US 6254853; WO 9958555
合成路线图解说明:

The lithium phenoxide obtained from propofol (I) and butyllithium is condensed with phosphoryl chloride to produce, after aqueous work up, the phosphate ester (II). Subsequent neutralization of an ethanolic solution of (II) with 1 M NaOH gives rise to the corresponding disodium salt.

参考文献No.54093
标题:Water-soluble prodrugs of propofol for treatment of migraine
作者:Hendler, S.S. (Vyrex Corp.)
来源:WO 0213810
合成路线图解说明:

The lithium phenoxide obtained from propofol (I) and butyllithium is condensed with phosphoryl chloride to produce, after aqueous work up, the phosphate ester (II). Subsequent neutralization of an ethanolic solution of (II) with 1 M NaOH gives rise to the corresponding disodium salt.

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