【药物名称】RX-72601
化学结构式(Chemical Structure):
参考文献No.804021
标题:RX 72601
作者:Casta馿r, J.; Hopkins, S.J.
来源:Drugs Fut 1976,1(6),304
合成路线图解说明:

A mixture of 2-(3-methoxyphenyl)cyclohexanone (I), pyrrolidine (II) and formic acid is heated at 130-40 C to give cis-2-(3-methoxyphenyl)-1-pyrrolidylcyclohexane (III), which is demethylated with refluxing HBr (47%) giving cis-2-(3-hydroxyphenyl)-1-pyrrolidylcyclohexane (IV). Finally this tertiary amine is quaternized with CH3Br.

参考文献No.804022
标题:Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors
作者:Singh, S.K.; Saibaba, V.; Ravikumar, V.; Rudrawar, S.V.; Daga, P.; Rao, C.S.; Akhila, V.; Hedge, P.; Rao, Y.K.
来源:J Pharm Pharmac 1974,26(8),134
合成路线图解说明:

A mixture of 2-(3-methoxyphenyl)cyclohexanone (I), pyrrolidine (II) and formic acid is heated at 130-40 C to give cis-2-(3-methoxyphenyl)-1-pyrrolidylcyclohexane (III), which is demethylated with refluxing HBr (47%) giving cis-2-(3-hydroxyphenyl)-1-pyrrolidylcyclohexane (IV). Finally this tertiary amine is quaternized with CH3Br.

参考文献No.900248
标题:
作者:Lewis, J.W. (Reckitt & Colman Pharmaceuticals)
来源:FR 2187296
合成路线图解说明:

A mixture of 2-(3-methoxyphenyl)cyclohexanone (I), pyrrolidine (II) and formic acid is heated at 130-40 C to give cis-2-(3-methoxyphenyl)-1-pyrrolidylcyclohexane (III), which is demethylated with refluxing HBr (47%) giving cis-2-(3-hydroxyphenyl)-1-pyrrolidylcyclohexane (IV). Finally this tertiary amine is quaternized with CH3Br.

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