-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	69793
标题:	Hypolipidemic and antioxidant morpholine derivs.
作者:	Chrysselis, M.; Rekka, E.; Kourounakis, P. (Elpen Pharm. Co.)
来源:	CA 2359476; EP 1140877; US 6693192; WO 0042030

合成路线图解说明: Condensation of 4-bromoacetylbiphenyl (I) with N-methyl ethanolamine (II) leads to the 2-hydroxymorpholine (III). The acid-catalyzed reaction of the hemiketal (III) with 3-bromo-1-propanol (IV) gives the bromopropoxy morpholine (V), which is finally converted into the title nitrate ester by treatment with AgNO3 in acetonitrile. (1,2)

参考文献No.	706856
标题:	Nitric oxide releasing morpholine derivatives as hypolipidemic and antioxidant agents
作者:	Chrysselis, M.C.; Rekka, E.A.; Siskou, I.C.; Kourounakis, P.N.
来源:	J Med Chem 2002,45(24),5406

合成路线图解说明: Condensation of 4-bromoacetylbiphenyl (I) with N-methyl ethanolamine (II) leads to the 2-hydroxymorpholine (III). The acid-catalyzed reaction of the hemiketal (III) with 3-bromo-1-propanol (IV) gives the bromopropoxy morpholine (V), which is finally converted into the title nitrate ester by treatment with AgNO3 in acetonitrile. (1,2)