BMS-292655-药物合成数据库

【药物名称】BMS-292655

化学结构式(Chemical Structure):

参考文献No.	43625
标题:	Water soluble prodrugs of azole cpds.
作者:	Hudyma, T.W.; Kim, O.K.; Zheng, X. (Bristol-Myers Squibb Co.)
来源:	WO 0030655

合成路线图解说明: The condensation of BMS-207147 (I) with 3-(chloromethyl)benzoic acid chloromethyl ester (II) (obtained by esterification of 3-(chloromethyl)benzoyl chloride (III) with paraformaldehyde and ZnCl2) by means of KH in THF gives the adduct (IV), which is condensed with phosphoric acid di-tert-butyl ester (V) to yield the phosphate (V). Finally, this compound is hydrolyzed with TFA in dichloromethane and treated with NaHCO3 to provide the target sodium salt.

参考文献No.	694057
标题:	BMS-292655, a soluble prodrug of the clinically efficacious antifungal triazole, BMS-207147 (ravuconazole)
作者:	Hudyma, T.W.; Zheng, X.; Clark, J.; et al.
来源:	42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002,Abst F-816

合成路线图解说明: The condensation of BMS-207147 (I) with 3-(chloromethyl)benzoic acid chloromethyl ester (II) (obtained by esterification of 3-(chloromethyl)benzoyl chloride (III) with paraformaldehyde and ZnCl2) by means of KH in THF gives the adduct (IV), which is condensed with phosphoric acid di-tert-butyl ester (V) to yield the phosphate (V). Finally, this compound is hydrolyzed with TFA in dichloromethane and treated with NaHCO3 to provide the target sodium salt.