【药物名称】JNJ-17297709
化学结构式(Chemical Structure):
参考文献No.34702
标题:Substd. tetracyclic tetrahydrofuran derivs.
作者:Gil-Lopetegui, P.; Fern醤dez-Gadea, F.J.; Meert, T.F. (Janssen Pharmaceutica NV)
来源:EP 0892793; JP 2000508327; WO 9738991
合成路线图解说明:

Reduction of dibenzosuberenone (I) with in situ generated AlH3 affords dibenzocycloheptene (II). Subsequent epoxidation of (II) employing m-chloroperbenzoic acid gives the dibenzocycloheptaoxirane (III) (1). Epoxide ring opening in (III) with allylmagnesium bromide produces the trans alcohol (IV). Bromination of the double bond of (IV) with pyridinium tribromide leads to the trans-fused tetrahydrofuran derivative (V) as a mixture of 4 diastereoisomers. Then, substitution of the bromide ion of (V) with dimethylamine, followed by chromatographic separation of the isomers provides the target compound.

参考文献No.687874
标题:Synthesis of 2-aminomethyl-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives as potential anxiolytic agents
作者:Alonso, J.M.; Andr閟, J.I.; Cid, J.M.; et al.
来源:Drugs Fut 2002,27(Suppl. A),
合成路线图解说明:

Reduction of dibenzosuberenone (I) with in situ generated AlH3 affords dibenzocycloheptene (II). Subsequent epoxidation of (II) employing m-chloroperbenzoic acid gives the dibenzocycloheptaoxirane (III) (1). Epoxide ring opening in (III) with allylmagnesium bromide produces the trans alcohol (IV). Bromination of the double bond of (IV) with pyridinium tribromide leads to the trans-fused tetrahydrofuran derivative (V) as a mixture of 4 diastereoisomers. Then, substitution of the bromide ion of (V) with dimethylamine, followed by chromatographic separation of the isomers provides the target compound.

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