【药物名称】STO-609
化学结构式(Chemical Structure):
参考文献No.679494
标题:STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase
作者:Tokumitsu, H.; Inuzuka, H.; Ishikawa, Y.; Ikeda, M.; Saji, I.; Kobayashi, R.
来源:J Biol Chem 2002,277(18),15813
合成路线图解说明:

The title compound is prepared starting from the previously reported 3-bromo-1,8-naphthoylenebenzimidazole (I). Cyanation of (I) with cuprous cyanide in pyridine affords nitrile (II). This is then hydrolyzed to the target carboxylic acid employing sulfuric acid in aqueous acetic acid.

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