AF-2364-药物合成数据库

【药物名称】AF-2364

化学结构式(Chemical Structure):

参考文献No.	41440
标题:	3-Substd. 1-benzyl-1H-indazole derivs. as antifertility agents
作者:	Cheng, C.Y.; Silvestrini, B. (Angelini Pharmaceuticals Inc.)
来源:	US 6001865

合成路线图解说明: The described compound can be obtained by treatment of carboxaldehyde (I) with potassium acetate (II) and acetic anhydride.

合成路线图解说明: The title hydrazide is prepared by treatment of methyl 1-(2,4-dichlorobenzyl)indazole-3-carboxylate (I) with hydrazine hydrate in boiling acetic acid.

参考文献No.	683102
标题:	Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis
作者:	Cheng, C.Y.; Silvestrini, B.; Grima, J.; Mo, M.Y.; Zhu, L.J.; Johansson, E.; Saso, L.; Leone, M.G.; Palmery, M.; Mruk, D.
来源:	Biol Reprod 2001,65(2),449

合成路线图解说明: The title hydrazide is prepared by treatment of methyl 1-(2,4-dichlorobenzyl)indazole-3-carboxylate (I) with hydrazine hydrate in boiling acetic acid.