【药物名称】2-IBPO
化学结构式(Chemical Structure):
参考文献No.681640
标题:Synthesis and characterization of radioiodinated MD-230254: A new ligand for potential imaging of monoamine oxidase B activity by single photon emission computed tomography
作者:Hirata, M.; Kagawa, S.; Yoshimoto, M.; Ohmomo, Y.
来源:Chem Pharm Bull 2002,50(5),609
合成路线图解说明:

Alkylation of ethyl 4-hydroxybenzoate (I) with 2-iodobenzyl bromide (II) affords the 4-benzyloxybenzoate (III). Subsequent reaction of ester (III) with hydrazine hydrate produces the hydrazide (IV), which is subjected to a Michael reaction with acrylonitrile (V), yielding (VI). Finally, cyclization of the hydrazide (VI) with triphosgene gives rise to the target ozadiazole derivative.

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