【药物名称】
化学结构式(Chemical Structure):
参考文献No.677937
标题:Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC
作者:Kline, T.; Andersen, N.H.; Harwood, E.A.; Bowman, J.; Malanda, A.; Endsley, S.; Erwin, A.L.; Doyle, M.; Fong, S.; Harris, A.L.; Mendelsohn, B.; Mdluli, K.; Raetz, C.R.H.; Stover, K.; Witte, P.R.; Yabannavar, A.; Zhu, S.
来源:J Med Chem 2002,45(14),3112
合成路线图解说明:

Coupling of 4-allyloxy-3-trifluoromethoxybenzoic acid (I) with D-serine methyl ester (II) using HATU/HOAt affords amide (III). Subsequent treatment of the benzoyl serine derivative (III) with diethylaminosulfur trifluoride gives rise to the oxazoline (IV). Finally, displacement of the methyl ester group of (IV) with hydroxylamine in the presence of NaOMe produces the title racemic hydroxamic acid

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