-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	677938
标题:	II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenox}propionic acid (XK469)
作者:	Hazeldine, S.T.; Polin, L.; Kushner, J.; White, K.; Bouregeois, N.M.; Crantz, B.; Palomino, E.; Corbett, T.H.; Horwitz, J.P.
来源:	J Med Chem 2002,45(14),3130

合成路线图解说明: The title diaryl ether is prepared by condensation between 7-bromo-2-chloroquinoline (I) and (R)-2-(4-hydroxyphenoxy)propionic acid (II) in the presence of K2CO3 in hot DMF.