【药物名称】
化学结构式(Chemical Structure):
参考文献No.674913
标题:From imidazoles to pyrimidines: New inhibitors of cytokine release
作者:Wagner, G.K.; Laufer, S.A.
来源:J Med Chem 2002,45(13),2733
合成路线图解说明:

Condensation of 2-(4-fluorophenyl)-1-(4-pyridyl)ethanone (I) with dimethylformamide-dimethylacetal gives the enamino ketone (II). This is cyclized with thiourea (III) in the presence of NaOEt to produce the pyrimidine-2-thione (IV). Finally, S-alkylation of (IV) with 2-(methylsulfinyl)benzyl chloride (V) yields the target compound.

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