CMPD1, AXC-06728-药物合成数据库

【药物名称】CMPD1, AXC-06728

化学结构式(Chemical Structure):

参考文献No.	42973
标题:	Non-peptide GnRH agent, methods and intermediates for their preparation
作者:	Hong, Y.; Anderson, M.B.; Li, H.; Tompkins, E.V.; Luthin, D.R.; Faust, J.; Vazir, H.N.; Paderes, G.D.; Pathak, V.P.; Christie, L.C. (Agouron Pharmaceuticals, Inc.)
来源:	EP 1105120; WO 0020358

合成路线图解说明: The reaction of 5-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)furan-2-carboxylic acid (I) with SOCl2 gives the corresponding acyl chloride (II), which is then condensed with 2,4,6-trimethoxyaniline (III) to afford the target carboxamide.