【药物名称】
化学结构式(Chemical Structure):
参考文献No.662939
标题:Novel antineoplasic phosphonate nucleosides
作者:Chan, L.; Nghe, P.; Vaillancourt, L.; Bubenik, M.
来源:223rd ACS Natl Meet (April 7 2002, Orlando) 2002,Abst MEDI 207
合成路线图解说明:

The condensation between mesylate (I) and 2-amino-6-chloropurine (II) in the presence of Cs2CO3 affords nucleoside (III). Hydrolysis of (III) with trimethylsilyl bromide, followed by refluxing with HCl, provides the target phosphonic acid, which is finally isolated as the corresponding ammonium salt.

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