-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	68407
标题:	Imidazolidinone cpds.
作者:	Hsu, M.-C.; Li, W.-T.; Chang, C.-M.; Shia, K.-S.; Shih, S.-R.; Chern, J.-H.; Chen, S.-J. (National Health Research Institutes)
来源:	US 2003087936; US 6706739

合成路线图解说明: The reaction of pyridine-4-amine (I) with 2-chloroethyl isocyanate (II) in toluene gives N-(2-chloroethyl)-N'-(4-pyridyl)urea (III), which is cyclized by means of NaH in DMF/THF, yielding 1-(4-pyridyl)imidazolidin-2-one (IV). Finally, this compound is condensed with 4-(5-bromopentyloxy)biphenyl (V) by means of NaH in DMF to afford the target disubstituted imidazolidinone. (1,2)

参考文献No.	661642
标题:	Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: A novel class of potent and selective human enterovirus 71 inhibitors
作者:	Shia, K.-S.; Li, W.-T.; Chang, C.-M.; Hsu, M.C.; Chern, J.H.; Leong, M.K.; Tseng, S.N.; Lee, C.C.; Lee, Y.C.; Chen, S.J.; Peng, K.C.; Tseng, H.Y.; Chang, Y.L.; Tai, C.L.; Shih, S.R.
来源:	J Med Chem 2002,45(8),1644

合成路线图解说明: The reaction of pyridine-4-amine (I) with 2-chloroethyl isocyanate (II) in toluene gives N-(2-chloroethyl)-N'-(4-pyridyl)urea (III), which is cyclized by means of NaH in DMF/THF, yielding 1-(4-pyridyl)imidazolidin-2-one (IV). Finally, this compound is condensed with 4-(5-bromopentyloxy)biphenyl (V) by means of NaH in DMF to afford the target disubstituted imidazolidinone. (1,2)