-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	54611
标题:	Thioflavin derivs. for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
作者:	Wang, Y.; Klunk, W.E.; Mathis, C.A. Jr. (University of Pittsburgh)
来源:	WO 0216333

合成路线图解说明: Condensation of 2-aminothiophenol (I) with 4-nitrobenzoyl chloride (II) produces the benzothiazole (III). Reduction of the nitro group of (III) by means of SnCl2 in refluxing EtOH yields aniline (IV). Then, alkylation of (IV) with 11C-labeled iodomethane gives rise to the target 11C-methylated aniline.

参考文献No.	660559
标题:	A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
作者:	Mathis, C.A.; Bacskai, B.J.; Kajdasz, S.T.; McLellan, M.E.; Frosch, M.P.; Hyman, B.T.; Holt, D.P.; Wang, Y.; Huang, G.F.; Debnath, M.L.; Klunk, W.E.
来源:	Bioorg Med Chem Lett 2002,12(3),295

合成路线图解说明: Condensation of 2-aminothiophenol (I) with 4-nitrobenzoyl chloride (II) produces the benzothiazole (III). Reduction of the nitro group of (III) by means of SnCl2 in refluxing EtOH yields aniline (IV). Then, alkylation of (IV) with 11C-labeled iodomethane gives rise to the target 11C-methylated aniline.