【药物名称】Compound 301029, PG-301029, 301029
化学结构式(Chemical Structure):
参考文献No.45154
标题:Thiadiazolyl urea or thiourea derivs. for antiviral treatment
作者:Camden, J.B. (The Procter & Gamble Co.)
来源:JP 2002540156; US 6258831; WO 0057878
合成路线图解说明:

Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II). This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1). Finally, hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea

参考文献No.53595
标题:Viral treatment
作者:Camden, J.B. (The Procter & Gamble Co.)
来源:JP 2002540150; US 6245788; WO 0057869
合成路线图解说明:

Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II). This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1). Finally, hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea

参考文献No.53596
标题:Viral treatment
作者:Camden, J.B. (The Procter & Gamble Co.)
来源:US 6340696
合成路线图解说明:

Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II). This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1). Finally, hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea

参考文献No.53597
标题:Process for the preparation of 1,2,4-thiadiazoles
作者:Agyin, J.K. (The Procter & Gamble Co.)
来源:US 6297384
合成路线图解说明:

Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II). This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1). Finally, hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea

参考文献No.710926
标题:1,2,4-Thiadiazolylureas. A postcript to the oxidative cyclisation of thionoamidines
作者:Kurzer, F.
来源:J Chem Soc - Perkins Trans I 1985,(2),311
合成路线图解说明:

Condensation of benzoyl chloride (I) with ammonium thiocyanate in boiling acetone produces benzoyl isothiocyanate (II). This is then coupled with the known 3-amino-5-phenyl-1,2,4-thiadiazole (III) to afford the N-benzoyl thiourea (IV) (1). Finally, hydrolysis of (IV) under alkaline conditions gives rise to the target thiadiazolyl thiourea

参考文献No.710929
标题:Addition-cyclisations of ethoxycarbonyl isothiocyanate with hydrazine derivatives as a source of thiadiazoles and triazoles
作者:Kurzer, F.; Secker, J.L.
来源:J Heterocycl Chem 1989,26(2),355
合成路线图解说明:

In a similar method, 3-amino-5-phenyl-1,2,4-tiadiazole (I) is coupled with ethoxycarbonyl isothiocyanate to give the N-(ethoxycarbonyl)thiourea (II), which is then hydrolyzed to the title compound under alkaline conditions

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