BKM-570-药物合成数据库

【药物名称】BKM-570

化学结构式(Chemical Structure):

参考文献No.	55966
标题:	Anti-cancer cpds. and methods related thereto
作者:	Stewart, J.M.; Gera, L.; Chan, D.C.F.; York, E.; Bunn, P.
来源:	WO 0011022

合成路线图解说明: N-Boc-O-(2,6-Dichlorobenzyl)-L-tyrosine (I) is coupled to 4-amino-2,2,6,6-tetramethylpiperidine (II) using BOP in DMF to provide amide (III). The N-Boc protecting group of (III) is then removed by trifluoroacetic acid, yielding amine (IV). This is finally acylated with pentafluorocinnamic acid (V) in the presence of BOP/i-Pr2NEt to furnish the title compound (1,2).

参考文献No.	677708
标题:	Bradykinin-related compounds as new drugs for cancer and inflammation
作者:	Stewart, J.M.; Gera, L..; Chan, D.C.; Bunn, P.A. Jr.; York, E.J.; Simkeviciene, V.; Helfrich, B.
来源:	Can J Physiol Pharmacol 2002,80(4),275

合成路线图解说明: N-Boc-O-(2,6-Dichlorobenzyl)-L-tyrosine (I) is coupled to 4-amino-2,2,6,6-tetramethylpiperidine (II) using BOP in DMF to provide amide (III). The N-Boc protecting group of (III) is then removed by trifluoroacetic acid, yielding amine (IV). This is finally acylated with pentafluorocinnamic acid (V) in the presence of BOP/i-Pr2NEt to furnish the title compound (1,2).