【药物名称】CP-642959
化学结构式(Chemical Structure):
参考文献No.42781
标题:Carbamate and carbazate ketolide antibiotics
作者:Kaneko, T.; Su, W.-G.; Wu, Y.-J. (Pfizer Inc.)
来源:EP 1115732; WO 0017218
合成路线图解说明:

The condensation between 3-(bromoacetyl)pyridine (I) and either formamide or formamidine acetate produced the intermediate 4-(3-pyridyl)imidazole (II). Alternatively, intermediate (II) was prepared by palladium-catalyzed coupling between 1-trityl-4-iodoimidazole (III) and diethyl(3-pyridyl)borane (IV), followed by acidic deprotection of the resultant 1-trityl-4-(3-pyridyl)imidazole (V). In a further procedure, iodoimidazole (III) was converted to the corresponding Grignard reagent (VI), which was then coupled with 3-bromopyridine (VII) in the presence of ZnCl2 and palladium catalyst, yielding adduct (V). Subsequent acid-catalyzed deprotection gave intermediate (II). Michael addition of crotonaldehyde (VIII) to imidazole (II) furnished the (pyridylimidazolyl)butyraldehyde (IX). Condensation of aldehyde (IX) with the macrocyclic N-amino carbamate (X) produced the intermediate imine (XI), which was reduced to the corresponding amino derivative using sodium cyanoborohydride. The resultant epimeric mixture was separated by chromatography to provide the title (3R)-diastereoisomer. Alternatively, the reductive alkylation of (X) with aldehyde (IX) was carried out in the presence of sodium triacetoxyborohydride.

参考文献No.48548
标题:Synthesis of carbamate ketolide antibiotics
作者:Kaneko, T.; McMillen, W.T.; McLaughlin, R.W.; Ripin, D.H.B.; Vanerplas, B.C. (Pfizer Inc.)
来源:EP 1088828; JP 2001151792
合成路线图解说明:

The condensation between 3-(bromoacetyl)pyridine (I) and either formamide or formamidine acetate produced the intermediate 4-(3-pyridyl)imidazole (II). Alternatively, intermediate (II) was prepared by palladium-catalyzed coupling between 1-trityl-4-iodoimidazole (III) and diethyl(3-pyridyl)borane (IV), followed by acidic deprotection of the resultant 1-trityl-4-(3-pyridyl)imidazole (V). In a further procedure, iodoimidazole (III) was converted to the corresponding Grignard reagent (VI), which was then coupled with 3-bromopyridine (VII) in the presence of ZnCl2 and palladium catalyst, yielding adduct (V). Subsequent acid-catalyzed deprotection gave intermediate (II). Michael addition of crotonaldehyde (VIII) to imidazole (II) furnished the (pyridylimidazolyl)butyraldehyde (IX). Condensation of aldehyde (IX) with the macrocyclic N-amino carbamate (X) produced the intermediate imine (XI), which was reduced to the corresponding amino derivative using sodium cyanoborohydride. The resultant epimeric mixture was separated by chromatography to provide the title (3R)-diastereoisomer. Alternatively, the reductive alkylation of (X) with aldehyde (IX) was carried out in the presence of sodium triacetoxyborohydride.

合成路线图解说明:

A related synthetic procedure started from 2',4''-bis-O-acetyl-6-O-methylerythromycin A (XII). Treatment of diol (XII) with carbonyldiimidazole in the presence of DBU generated the anhydro imidazolide (XIII). Reaction of (XIII) with hydrazine gave rise to the N-amino cyclic carbamate (XIV). Selective cleavage of the cladinose moiety at position 3 under acidic conditions afforded (XV). The keto group of (XV) was then converted to the oxime (XVI) upon treatment with O-methyl hydroxylamine. Reductive alkylation of (XVI) with aldehyde (IX) in the presence of NaBH(OAc)3 provided adduct (XVII). Then, Swern oxidation of the 3-hydroxy group of (XVII) to the corresponding ketone, followed by hydrolysis of the acetate ester, furnished the title ketolide as a diastereomeric mixture.

合成路线图解说明:

The intermediate hydrazine (XXIII) was obtained by two alternative methods. Alkylation of 4-(3-pyridyl)imidazole (II) with the chiral mesylate (XIX), prepared from (R)-1,3-butanediol (XVIII), furnished, after desilylation with tetrabutylammonium fluoride, the imidazolyl butanol (XX). Condensation of alcohol (XX) with di-tert-butyl azodicarboxylate in the presence of PPh3 yielded the hydrazine dicarboxylate (XXII), which was then deprotected to hydrazine (XXIII) under acidic conditions.

合成路线图解说明:

In an alternative synthesis of hydrazine (XXIII), aldehyde (IX) was condensed with tert-butyl hydrazinecarboxylate (XXIV), producing hydrazone (XXV), which was further reduced to the hydrazinecarboxylate (XXVI) in the presence of NaBH(OAc)3. Acidic cleavage of the N-Boc group of (XXVI) provided hydrazine (XXIII).

合成路线图解说明:

The condensation of anhydro imidazolide (XIII) with the substituted hydrazine (XXIII) generated the cyclic carbamate (XXVII). After acidic cleavage of the cladinose moiety, the resultant ketone (XXVIII) was converted to the O-methyl oxime (XXIX). The title compound was then obtained by Swern oxidation of (XXIX) followed by basic hydrolysis.

参考文献No.646185
标题:The in vitro and in vivo activity of CP-642,959 and its related diastereomers
作者:Su, W.; et al.
来源:41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001, Chicago) 2001,Abst F-1168
合成路线图解说明:

The condensation between 3-(bromoacetyl)pyridine (I) and either formamide or formamidine acetate produced the intermediate 4-(3-pyridyl)imidazole (II). Alternatively, intermediate (II) was prepared by palladium-catalyzed coupling between 1-trityl-4-iodoimidazole (III) and diethyl(3-pyridyl)borane (IV), followed by acidic deprotection of the resultant 1-trityl-4-(3-pyridyl)imidazole (V). In a further procedure, iodoimidazole (III) was converted to the corresponding Grignard reagent (VI), which was then coupled with 3-bromopyridine (VII) in the presence of ZnCl2 and palladium catalyst, yielding adduct (V). Subsequent acid-catalyzed deprotection gave intermediate (II). Michael addition of crotonaldehyde (VIII) to imidazole (II) furnished the (pyridylimidazolyl)butyraldehyde (IX). Condensation of aldehyde (IX) with the macrocyclic N-amino carbamate (X) produced the intermediate imine (XI), which was reduced to the corresponding amino derivative using sodium cyanoborohydride. The resultant epimeric mixture was separated by chromatography to provide the title (3R)-diastereoisomer. Alternatively, the reductive alkylation of (X) with aldehyde (IX) was carried out in the presence of sodium triacetoxyborohydride.

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