RO-098246-药物合成数据库

【药物名称】RO-098246

化学结构式(Chemical Structure):

参考文献No.	52304
标题:	Azole derivs.
作者:	Shimma, N.; Tsukuda, T.; Komiyama, S. (Basilea Pharmaceutica AG)
来源:	US 6319933; WO 0179196

合成路线图解说明: Addition of trimethylsilyl cyanide to the known epoxide (I) produced the hydroxy nitrile (II). This was converted to the thioamide (III) upon treatment with diethyl dithiophosphate. Condensation between thioamide (III) and thiadiazolyl thiobenzamide (IV) in the presence of iodine furnished the target thiadiazole derivative.

参考文献No.	662473
标题:	Parallel synthesis of azole antifungals and identification of novel thiadiazole-containing antifungals
作者:	Fujii, T.; Tsukuda, T.; Shimma, N.; Komiyama, S.
来源:	223rd ACS Natl Meet (April 7 2002, Orlando) 2002,Abst MEDI 175

合成路线图解说明: Addition of trimethylsilyl cyanide to the known epoxide (I) produced the hydroxy nitrile (II). This was converted to the thioamide (III) upon treatment with diethyl dithiophosphate. Condensation between thioamide (III) and thiadiazolyl thiobenzamide (IV) in the presence of iodine furnished the target thiadiazole derivative.