Oxidative cleavage of 6-deoxy-beta-D-mannopyranosyl sordaricin (I) using sodium periodate furnished dialdehyde (II). Subsequent reductive amination of dialdehyde (II) gave rise to the morpholino derivative (III). Acidic hydrolysis of the ethylene ketal function of (III) provided aldehyde (IV). The carboxylic group was then protected as the benzhydryl ester (V) using diphenyl diazomethane. 2-Methylene-1,3-propanediol (VI) was converted to mono-tosylate (VII) by treatment with p-toluenesulfonyl chloride in the presence of dibutyltin oxide and N-methylimidazole. Subsequent hydroxyl group fluorination of (VII) by means of diethylaminosulfur trifluoride provided 2-(fluoromethyl)propenyl tosylate (VIII). Alkylation of the morpholine N of (V) with tosylate (VIII) gave adduct (IX). The benzhydryl ester of (IX) was finally cleaved to the title carboxylic acid by treatment with trifluoroacetic acid.