SPI-339, NEO-339-药物合成数据库

【药物名称】SPI-339, NEO-339

化学结构式(Chemical Structure):

参考文献No.	57947
标题:	Synthesis and methods of use of tetrahydroisoindolone analogues and derivs.
作者:	Foreman, M.M.; Glasky, A.J.; Fick, D.B. (Spectrum Pharmaceuticals, Inc.)
来源:	EP 1383742; WO 0285856

合成路线图解说明: The reaction of 4-aminobenzoic acid ethyl ester (I) with acryloyl chloride (II) by means of TEA in dichloromethane gives the corresponding acrylamide (III), which is condensed with 4,5,6,7-tetrahydro-1H-indol-4-one (IV) by means of K2CO3 in hot DMF to yield NEO-339. (1,2)

参考文献No.	686459
标题:	Search, design and discovery of NEO-339, a novel agent that increases attentional processes associated with cognition
作者:	Mohan, P.; Fick, D.B.; McKinley, L.K.; Prigaro, B.J.; Pfadenhauer, E.; Helton, D.
来源:	224th ACS Natl Meet (Aug 18 2002, Boston) 2002,Abst MEDI 249

合成路线图解说明: The reaction of 4-aminobenzoic acid ethyl ester (I) with acryloyl chloride (II) by means of TEA in dichloromethane gives the corresponding acrylamide (III), which is condensed with 4,5,6,7-tetrahydro-1H-indol-4-one (IV) by means of K2CO3 in hot DMF to yield NEO-339. (1,2)