【药物名称】
化学结构式(Chemical Structure):
参考文献No.635450
标题:A new class of ibuprofen derivatives with reduced gastrotoxicity
作者:Lolli, M.L.; Cena, C.; Medana, C.; Lazzarato, L.; Morini, G.; Coruzzi, G.; Manarini, S.; Fruttero, R.; Gasco, A.
来源:J Med Chem 2001,44(21),3463
合成路线图解说明:

The furazanyloxypropanol derivative (III) was obtained by condensation of 3,4-bis(benzenesulfonyl)furoxan (I) with 1,3-propanediol (II) in the presence of NaOH. Subsequent acylation of alcohol (III) with ibuprofen acid chloride (IV) provided the corresponding ibuprofen ester.

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