BMS-379224-药物合成数据库

【药物名称】BMS-379224

化学结构式(Chemical Structure):

参考文献No.	50293
标题:	Water soluble prodrugs of azole cpds.
作者:	Hudyma, T.W.; Golik, J.; Ueda, Y.; Chen, C.-P.; Matiskella, J.D. (Bristol-Myers Squibb Co.)
来源:	EP 1284737; US 6362172; WO 0152852

合成路线图解说明: The condensation of BMS-207147 (I) with phosphoric acid di-tert-butyl chloromethyl triester (II) by means of NaH in THF gives the phosphoric triester (III), which is finally hydrolyzed with TFA in dichloromethane and treated with Na2CO3 to provide the target disodium salt.

参考文献No.	694058
标题:	BMS-379224, a water-soluble prodrug of ravuconazole
作者:	Ueda, Y.; Barbour, N.; Bronson, J.J.; et al.
来源:	42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002,Abst F-817

合成路线图解说明: The condensation of BMS-207147 (I) with phosphoric acid di-tert-butyl chloromethyl triester (II) by means of NaH in THF gives the phosphoric triester (III), which is finally hydrolyzed with TFA in dichloromethane and treated with Na2CO3 to provide the target disodium salt.