【药物名称】Tiodonium chloride, DL-164
化学结构式(Chemical Structure):
参考文献No.803968
标题:Tiodonium chloride
作者:Casta馿r, J.; Blancafort, P.
来源:Drugs Fut 1977,7(6),407
合成路线图解说明:

The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III), which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V). Finally this salt is treated with HCl in aqueous formic acid. (1-4)

参考文献No.900200
标题:
作者:Moyle, C.L. (Dow Chem. Co.)
来源:FR 2153532
合成路线图解说明:

The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III), which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V). Finally this salt is treated with HCl in aqueous formic acid. (1-4)

参考文献No.900201
标题:
作者:Moyle, C.L. (Dow Chem. Co.)
来源:US 3763187
合成路线图解说明:

The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III), which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V). Finally this salt is treated with HCl in aqueous formic acid. (1-4)

参考文献No.900202
标题:
作者:Moyle, C.L. (Dow Chem. Co.)
来源:US 3885036
合成路线图解说明:

The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III), which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V). Finally this salt is treated with HCl in aqueous formic acid. (1-4)

参考文献No.900203
标题:
作者:Moyle, C.L. (Dow Chem. Co.)
来源:DE 2145733; GB 1351531
合成路线图解说明:

The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III), which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V). Finally this salt is treated with HCl in aqueous formic acid. (1-4)

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