Tiprenolol hydrochloride, DU-21445-药物合成数据库

【药物名称】Tiprenolol hydrochloride, DU-21445

化学结构式(Chemical Structure):

参考文献No.	803976
标题:	Tiprenolol hydrochloride
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Weetman, D.F.
来源:	Drugs Fut 1979,4(11),830

合成路线图解说明: The condensation of o-(methylthio)phenol (I) with epichlorohydrin (II) by means of sodium hydroxide in water gives 3-[o-(methylthio)phenoxy]-1,2-epoxypropane (III), which is then treated with isopropylamine (IV) in hot water and finally with ethanolic HCl

参考文献No.	900210
标题:
作者:	(N.V. Philips' Gloeilampenfabrieken)
来源:	BE 679005; CA 832495; DE 1543790; FR 1552786; FR 6393; GB 1137764; JP 6902978; NL 6504268; US 3542874; US 3632780

合成路线图解说明: The condensation of o-(methylthio)phenol (I) with epichlorohydrin (II) by means of sodium hydroxide in water gives 3-[o-(methylthio)phenoxy]-1,2-epoxypropane (III), which is then treated with isopropylamine (IV) in hot water and finally with ethanolic HCl